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Children exposed to phenytoin in utero had a mean(+/-SD)global IQ 10 points lower(95%confidence interval,4.9 to 15.8 points)than their matched controls(113.4+/-13.1 and 103.3+/-25.1;P=.038).The Reynell language development scores followed a similar trend,with children exposed to phenytoin scoring significantly lower than their controls.Phenytoin- exposed children had a global IQ of 84 or less significantly more often than the control group(P<.01).Children exposed in utero to carbamazepine did not differ from their controls on any of the neurobehavioral tests.Our study suggests a clinically important negative effect of phenytoin on neurobehavioral development,independent of maternal or environmental factors,causing a substantial number of children to achieve a lower score than expected on cognitive tests.No similar effects could be shown after gestational use of carbamazepine. |
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adverse drug reaction
anticonvulsants,cognitive function with
anticonvulsants,untoward effects of
carbamazepine
congenital malformation,dilantin therapy causing
developmental evaluation
dilantin
dilantin,toxicity
intelligence quotient
intelligence testing in children
intrauterine
pregnancy,neurologic complications in
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psychological testing,children
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